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- Title
LncRNA CTBP1-AS2 Influences Cellular Activities via miR-381-3p/ID1 Axis in Breast Cancer.
- Authors
Zhou, H. F.; Liu, B.; Duan, J. W.; Zhang, S. Y.; Fan, Y. H.
- Abstract
LncRNAs are involved in a variety of physiological and pathological processes. Whereas, the putative role of lncRNAs in breast cancer remains largely elusive. Herein, we investigated the influence of lncRNA CTBP1-AS2 in breast cancer. The expression of lncRNA CTBP1-AS2 was detected in breast cancer tissues. The possible clinical value of CTBP1-AS2 was evaluated using the Kaplan–Meier curve. The influences of CTBP1-AS2 on tumor cell abilities were determined by in vitro experiments. Online databases and dual-luciferase reporter assay were used to reveal the interaction between CTBP1-AS2, miR-381-3p, and ID1. LncRNA CTBP1-AS2 expression showed rising trend in breast cancer tissues and forecasted a poor survival outcome in breast cancer patients. Functionally, CTBP1-AS2 knockdown inhibited tumor cell growth and invasion in vitro. Mechanistically, CTBP1-AS2 may competitively bind with miR-381-3p and then regulate ID1 to act as a tumor-promoter in breast cancer. Collectively, these results reveal the potential role of lncRNA CTBP1-AS2 in breast cancer and a novel CTBP1-AS2/miR-381-3p/ID1 pathway for tumor progression and suggest that CTBP1-AS2 may be a potential prognostic predictor and therapeutic target for patients with breast cancer.
- Subjects
LINCRNA; BREAST cancer; ONLINE databases; CANCER prognosis; PROGNOSTIC models; SURVIVAL rate
- Publication
Russian Journal of Genetics, 2023, Vol 59, p90
- ISSN
1022-7954
- Publication type
Article
- DOI
10.1134/S1022795423130148