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- Title
Analysis of FOXO1A and FOXO3A gene allele association with human longevity.
- Authors
Erdman, V.; Nasibullin, T.; Tuktarova, I.; Somova, R.; Mustafina, O.
- Abstract
Seeking human longevity association with gene polymorphisms in transcription factors in the Tatar ethnic group, we conducted an analysis for age-related genotype frequencies in polymorphic sites of FOXO1A (rs4943794, 72327C>G) and FOXO3A (rs3800231, 35-2764A>G) genes. Genotyping was conducted using the PCR-RFLP approach. According to the results of logistic regression analysis, during maturity and old age periods, a decrease in the number of FOXO1A* G/* G (OR = 0.984, P = 0.004) genotype carriers occurs and an increase in the number of FOXO1A* C/* G (OR = 1.035, P = 0.014) and FOXO1A* C/* C (OR = 1.024, P = 0.033) genotype carriers occurs in the sample of subjects before gender adjustments. In the sample of long-livers, the number of FOXO1A* C/* C (OR = 0.772, P = 0.028) genotype carriers decreased among women, while the number of FOXO3A* G/* G (OR = 1.008, P = 0.0001) genotype carriers increased among both men and women. Therefore, the FOXO1A gene polymorphic site rs4943794 is associated with an acquisition of old and senescent age in a sample before gender adjustments and with women's longevity. FOXO3A gene polymorphic site rs3800231 is associated with longevity in both women and men.
- Subjects
GENETICS of longevity; ALLELES; GENETIC polymorphisms; TRANSCRIPTION factors; LOGISTIC regression analysis; GENOTYPES
- Publication
Russian Journal of Genetics, 2016, Vol 52, Issue 4, p416
- ISSN
1022-7954
- Publication type
Article
- DOI
10.1134/S1022795416020034