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- Title
Bixa orellana Leaves Extract Inhibits Bradykinin-Induced Inflammation through Suppression of Nitric Oxide Production.
- Authors
Keong, Y. Yoke; Arifah, A. K.; Sukardi, S.; Roslida, A. H.; Somchit, M. N.; Zuraini, A.
- Abstract
Objective: The present study was conducted to assess the anti-inflammatory effect of a crude aqueous extract of Bixa orellana leaves (AEBO) and to examine the possible involvement of nitric oxide (NO) in its anti-inflammatory mechanism. Materials and Methods: The air-dried, powdered leaves were soaked in distilled water (1:20 w/v) at 50°C for 24 h and the supernatant obtained was freeze-dried (yield 8.5% w/w). The dosage was recorded as the mass of extract per kg b.w. of rats in all inflammatory assays (bradykinin-induced paw edema, peritoneal vascular permeability and NO assay). Results: Pretreatment with AEBO for 4 consecutive days exhibited significant inhibitory activity against inflammatory models, the bradykinin-induced hind paw edema model and bradykinin-induced increased peritoneal vascular permeability at both doses in dose-dependent manner. In addition, AEBO was also found to significantly suppress the production of NO at doses of 50 and 150 mg/kg. Conclusion: This study provides scientific data to support the traditional use of B. orellana leaves in treating inflammation. Results from this study suggest that AEBO exerts anti-inflammatory effects. Part of this anti-inflammatory effect may be associated with its antibradykinin activity and may be related to a reduction of the NO production. Copyright © 2011 S. Karger AG, Basel
- Subjects
ANTI-inflammatory agents; ANNATTO tree; NITRIC oxide; DISTILLED water; DRUG dosage
- Publication
Medical Principles & Practice, 2011, Vol 20, Issue 2, p142
- ISSN
1011-7571
- Publication type
Article
- DOI
10.1159/000319907