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- Title
Coupling herpesvirus to angiogenesis.
- Authors
Boshoff, Chris
- Abstract
Describes research which reported that the G-protein-coupled receptor (GPCR) encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) induces an angiogenic switch in transformed NIH3T3 cells. Spindle cells in KSHV; KSHV-GPCR fully active in absence of chemokine ligands; Other viral oncogenes inducing tumor formation and angiogenesis; Oncogenic cluster of proteins; Herpesviral proteins either latent or lytic; KSHV-GPCR in B cells. INSET: Viral pirates on a cellular sea, by C.B..
- Subjects
KAPOSI'S sarcoma; HERPESVIRUS disease genetics; REGULATION of neovascularization; MOLECULAR carcinogenesis; GENETICS
- Publication
Nature, 1998, Vol 391, Issue 6662, p24
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/34054