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- Title
Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases.
- Authors
Viken, M. K.; Amundsen, S. S.; Kvien, T. K.; Boberg, K. M.; Gilboe, I. M.; Lilleby, V.; Sollid, L. M.; Førre, ØT; Thorsby, E.; Smerdel, A.; Lie, B. A.
- Abstract
A functional single nucleotide polymorphism, 1858C>T, in the PTPN22 gene, encoding a tyrosine phosphatase, has been reported to be associated with type I diabetes and some other autoimmune diseases. To further investigate whether this polymorphism may be a general susceptibility factor for autoimmunity, we performed an association study in five different autoimmune diseases, three previously not tested. We found an association with juvenile idiopathic arthritis (OR=1.41; P=0.04), not previously reported, and a tendency for an association with coeliac disease (OR=1.35; P=0.08). In primary sclerosing cholangitis, no association was observed (OR=0.95; P=0.8). Furthermore, we confirmed the increased risk in rheumatoid arthritis (OR=1.58; P=0.001), but could not find support for an association with systemic lupus erythematosus (OR=0.94; P=0.8). Altogether, we have provided further evidence of an association between autoimmune diseases and the 1858C>T polymorphism in PTPN22.Genes and Immunity (2005) 6, 271-273. doi:10.1038/sj.gene.6364178 Published online 10 March 2005
- Subjects
PROTEIN-tyrosine phosphatase; DIABETIC acidosis; BLOOD hyperviscosity syndrome; LUPUS erythematosus; VASCULAR diseases; TYROSINE
- Publication
Genes & Immunity, 2005, Vol 6, Issue 3, p271
- ISSN
1466-4879
- Publication type
Article
- DOI
10.1038/sj.gene.6364178