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- Title
Pan-cancer analysis, providing a reliable basis for IDO2 as a prognostic biomarker and target for immunotherapy.
- Authors
Bangqian Mo; Xiashuang Zhao; Yongfeng Wang; Xianglai Jiang; Deming Liu; Hui Cai
- Abstract
Objectives: Indoleamine 2,3-dioxygenase 2 (IDO2) is a homologous protein of the classical immune negative regulator Indoleamine 2,3-dioxygenase 1 (IDO1) that is indispensable in the metabolism of tryptophan and is closely related to the pathogenesis and progression of tumors. Nevertheless, the mechanism of IDO2 in malignant tumors is not fully understood warranting further research. Methods: Data related to IDO2 in pan-cancer was obtained from The Cancer Genome Atlas (TCGA) database. Differences in IDO2 expression between pan-cancerous and corresponding normal tissues were analyzed, and survival rates were analyzed using Kaplan--Meier. The correlation between IDO2 expression and tumor-infiltrating immune cells (TIICs), tumor mutational load (TMB), microsatellite instability (MSI), mismatch repair (MMR), immune checkpoints (ICP) and DNA methyltransferase (DNMT) was investigated by Spearman correlation analysis. Functional enrichment analysis of IDO2 was performed to explore its biological and molecular roles in tumors.
- Subjects
INDOLEAMINE 2,3-dioxygenase; TUMOR-infiltrating immune cells; IMMUNE checkpoint proteins; GENETIC load; IMMUNOTHERAPY
- Publication
Oncologie (De Gruyter), 2023, Vol 25, Issue 1, p17
- ISSN
1765-2839
- Publication type
Article
- DOI
10.1515/oncologie-2022-1026