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- Title
Is a Total Colectomy a Better Surgical Treatment for Spontaneous Colonic Perforation that Developed during Bevacizumab Treatment for Extra-intestinal Cancers?
- Authors
Baltacı, Ege; Demir, Atakan; Baca, Bilgi; Demir, Gökhan; Hamzaoğlu, İsmail; Özben, Volkan; Aghayeva, Afag; Bilgin, Ahmet İsmail; Bozkırlı, Bahadır Osman; Aytaç, Erman; Karahasanoğlu, Tayfun
- Abstract
Spontaneous colonic perforation (SCP) is a life-threatening complication of bevacizumab treatment, but data on its management is insufficient. We present five cases of SCP in patients who were receiving bevacizumab for extra-intestinal malignancies. Patients who underwent a partial colectomy at the perforation site (n=3) suffered from ongoing abdominal sepsis postoperatively and died within a month. In contrast, patients who underwent total colectomy (n=2) had a relatively prolonged survival and eventually died of primary disease progression. Considering the pathophysiology of bevacizumab-related SCP, a total colectomy can be a life-saving and definitive procedure when non-perforated segments of the colon appear unhealthy during intraoperative exploration.
- Subjects
COLECTOMY; CASE studies; SURGICAL complications; TUMORS; TREATMENT effectiveness; BEVACIZUMAB; DISEASE progression; INTESTINAL perforation
- Publication
Turkish Journal of Colorectal Disease, 2020, Vol 30, Issue 4, p319
- ISSN
2536-4898
- Publication type
Article
- DOI
10.4274/tjcd.galenos.2020.2020-1-1