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- Title
Beyond Boveri.
- Authors
Robey, Rebecca
- Abstract
The article discusses the results of a study on centrosome dysfunction and genomic instability in cancer cells, by Thea Tlsty and colleagues. The authors investigated the classic hypothesis by Theodor Boveri that aneuploidy results from an increase in the number of centrosomes. They used a variant population of primary human mammary epithelial cells to show that the additional centrosomes are not due to polyploidy. They also showed that this additional centrosomes are generated by centriole-pair splitting and that p16INK4a must therefore prevent this during S phase.
- Subjects
CENTROSOMES; CANCER cells; ANEUPLOIDY; POLYPLOIDY; CANCER research; TLSTY, Thea; BOVERI, Theodor
- Publication
Nature Reviews Cancer, 2006, Vol 6, Issue 5, p340
- ISSN
1474-175X
- Publication type
Article
- DOI
10.1038/nrc1903