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- Title
Preliminary Effect of Cottonseed as a Source of Gossypol on Hepatic Portal Blood Flow as an Indicator of Metabolism in Meat does Artificially Infected with Haemonchus Contortus.
- Authors
Callender, Emily; Marchant, Nicolas; Dearborn, Lindsey; Contreras-Correa, Zully E.; Lemley, Caleb O.; Pesato, Michael; Rios, Leyla
- Abstract
Cottonseed diets provide animals with increased levels of protein and energy to support growth. Recently, it was suggested that although the gossypol content of cottonseed could result in adverse animal reproduction, it could have a potential anthelmintic property beneficial to small ruminant operations. In addition, gossypol is primarily cleared and excreted from the animal via liver glucuronidation, which is a primary pathway for steroid clearance in ruminants. The objective of this experiment was to determine the effect of a cottonseed diet and parasite load on the hepatic portal blood flow an indicator of hepatic clearance rates and metabolism. Forty Boer x Spanish cross does were assigned to of 4 treatments (n = 10 per treatment group) in a 2x2 factorial design consisting of cottonseed supplementation and no parasite infection (CNP), cottonseed supplementation plus artificial infection with Haemonchus contortus (CP), commercial pellets with no parasite infection (NCNP), or commercial pellets plus artificial infection with Haemonchus contortus (NCP). On week 8 post-treatment, hepatic portal blood flow measurements were collected via Doppler ultrasonography on the right side of the animal at the 10th intercostal space. Blood flow was then calculated using the following equation: blood flow (mL/min) = mean velocity (cm/s) x vessel area x 60 seconds. The mean velocity was calculated by the following formula: (systolic - diastolic)/pulsatility index. Hepatic portal blood flow and body weight of does were analyzed with a One-way ANOVA using the MIXED procedure of SAS with diet and parasite load as the main effects and their interactions. A diet by parasite interaction (P = 0.026) was observed for the mean velocity of the hepatic portal vein, which was decreased in CP versus CNP treatments. A diet by parasite interaction (P = 0.012) was observed for the diameter of the hepatic portal vein, which was increased in the CP treatment versus all other groups. However, absolute hepatic portal blood flow was not different (P > 0.12) amongst treatments. A tendency for the main effect (P = 0.087) of diet was observed for hepatic portal blood flow relative to body weight, which was an increase in cottonseed (27.8 ±.8 mL/min*kg) versus NCS (23.2 ±.8 mL/min*kg). Body weight was not different (P > 0.35) amongst treatments at the time of Doppler ultrasound examination. In conclusion, cottonseed interacted with parasites to decrease mean velocity and increase the diameter of the portal vein. In addition, cottonseed appears to increase liver blood flow relative to body weight. This change in relative liver blood flow could have implications for mediating hepatic metabolism and clearance.
- Subjects
BLOOD flow; HAEMONCHUS contortus; COTTONSEED; GOSSYPOL; REPRODUCTION; BLOOD flow measurement; DOPPLER ultrasonography
- Publication
Journal of Animal Science, 2023, Vol 101, p115
- ISSN
0021-8812
- Publication type
Article
- DOI
10.1093/jas/skad068.138