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- Title
Estimation of genome wide haplotype effects in half-sib designs.
- Authors
Kolbehdari, D.; Schaeffer, L. R.; Robinson, J. A. B.
- Abstract
Methods of scoring haplotype transmission in half-sib designs combined with linear mixed haplotype model were proposed to locate and estimate QTL effects within a 100 cM region of DNA. Precision, average of absolute effects of haplotypes, and correlation between estimated and true breeding values were used to compare scenarios via Monte Carlo simulation of granddaughter designs. Factors studied were the size of QTLs, heritability of quantitative trait, and the positions of QTL. Markers and QTLs were assumed to be bi-allelic. One hundred equally spaced markers (1 cM) with ten QTLs located between markers were simulated. Marker haplotypes were constructed for each pair of contiguous markers. Scores were used to indicate haplotype transmission from sire to son based on marker haplotypes. The scores were used in a linear mixed model across the population. The linear mixed haplotype model was successful model to estimate and locate effects of QTL in granddaughter designs. QTLs of equal magnitude gave slightly higher precision than QTLs of unequal size. Correlations between estimated and true breeding values ranged from 0.72 to 0.85. The linear mixed haplotype model could be used to estimate QTL positions and effects within intervals of 1 cM.
- Subjects
MONTE Carlo method
- Publication
Journal of Animal Science, 2006, Vol 84, p169
- ISSN
0021-8812
- Publication type
Article