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- Title
Pre-Clinical Safety Evaluation of Pyrrolidine Dithiocarbamate.
- Authors
Chabicovsky, Monika; Prieschl-Grassauer, Eva; Seipelt, Joachim; Muster, Thomas; Szolar, Oliver H. J.; Hebar, Alexandra; Doblhoff-Dier, Otto
- Abstract
Pyrrolidine dithiocarbamate (PDTC) was examined for its potential in the intranasal treatment of human rhinovirus infections. Prior to clinical testing, a comprehensive non-clinical programme was performed to evaluate the general toxicity of PDTC. The animal experiments included investigations in rodents with study durations ranging from single dose to repeated dosing over a period of 28 days. The routes of administration were intranasal, inhalative, oral and intravenous for single-dose toxicity and pharmacokinetic studies, and intranasal for repeated dose studies. Blood and tissue samples were obtained from PDTC-treated rats to analyse pharmacokinetics and tissue distribution. Accumulation of selected metals due to PDTC treatment was examined in liver, brain, nerves and fat tissues.
- Subjects
DITHIOCARBAMATES; COMMON cold treatments; CLINICAL drug trials; CLINICAL pharmacology; LABORATORY rodents; ANIMAL models of toxicology
- Publication
Basic & Clinical Pharmacology & Toxicology, 2010, Vol 107, Issue 3, p758
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/j.1742-7843.2010.00573.x