We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Detection of anti Hepatitis B core antibodies among Hepatitis B surface antigen negative blood donors in Sana ’a city, Yemen.
- Authors
خالد عبد الكريم المؤيد; أحمد محمد الحداد; وليد عبد الواسع سلام
- Abstract
Hepatitis B is still a serious global infectious disease that remains a high risk for patients requiring blood transfusions, despite the introduction of appropriate methods for diagnosis of the causative virus in blood banks, thus this cross-sectional study aimed to estimate anti-HBc (IgM and IgG) antibodies in blood donors who were HBsAg negative, to determine HBV-DNA among the positive anti-HBc blood donors and finally to study the association of positive anti-HBc Abs donors with the predisposing factors contributing for HBV transmission in Sana'a city, Yemen. This study included 700 Yemeni male blood donors who came for blood donation to the National Center for Blood Transfusion and Research in Sana'a city during a one year period (January - December 2010). Their age ranged from < 20 years to ≥ 40 years old with a mean age of 38 years and a standard deviation (SD) of 6.9 years. Blood samples and information data were collected from each subject recruited in the study. Serum was separated and tested for anti-HBc antibodies and HBV-DNA by an automated ELISA and RT-PCR method. Data were analyzed by SPSS (version 15) for statistical significance. In this study, the prevalence of anti-HBc-IgG among the studied subjects was 9%, whereas the prevalence of anti-HBc-IgM was zero. HBV-DNA was detected in 4.8% of these positive anti-HBc-IgG subjects. This study showed that blood donors with positive anti-HBc- IgG had a significant association with increased age. The main predisposing factors that had a significant association with positive anti- HBc-IgG subjects were blood transfusion, history of jaundice and family history for hepatitis. It can be concluded from this study that there was a relatively high positive percentage for both anti-HBc-IgG and HBV-DNA among subjects who were HBs Ag negative. Increased age, previous blood transfusions, history of jaundice and family history of hepatitis were the main predisposing factors associated with positive anti-HBc-IgGsubjects.
- Subjects
YEMEN (Republic); SANA (Yemen); HEPATITIS associated antigen; HEPATITIS B; BLOOD donors; BLOOD transfusion; IMMUNOGLOBULINS
- Publication
Al-Andalus journal for Humanities & Social Sciences, 2020, Issue 29, p3
- ISSN
2410-1818
- Publication type
Article