We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impact of hepatobiliary phase liver MRI versus Contrast-Enhanced Ultrasound after an inconclusive extracellular gadolinium-based contrast-enhanced MRI for the diagnosis of benign hepatocellular tumors.
- Authors
Tselikas, Lambros; Pigneur, Frederic; Roux, Marion; Baranes, Laurence; Costentin, Charlotte; Roche, Vincent; Calderaro, Julien; Herin, Edouard; Laurent, Alexis; Zafrani, Elie; Azoulay, Daniel; Mallat, Ariane; Rahmouni, Alain; Luciani, Alain
- Abstract
Purpose: To compare the added values of hepatobiliary phase (HBP) MRI and contrast-enhanced ultrasound (CEUS) in addition to inconclusive extracellular gadolinium-based contrast-enhanced MRI (CE-MRI) to characterize benign hepatocellular tumors (BHT). Methods: Eighty-three BHT-46 focal nodular hyperplasia (FNH) and 37 hepatocellular adenomas (HCA)-with inconclusive CE-MRI in 54 patients (43 women and 11 men, mean age 42 years old ± 14.8) were retrospectively analyzed. All patients underwent both HBP-MRI and CEUS. Two radiologists independently reviewed 2 sets of images, SET-1: CE-MRI and HBP-MRI; SET-2: CE-MRI and CEUS, and classified lesions as 'definite FNH,' 'possible FNH,' or 'definitely not FNH.' Sensitivity (Se) and specificity (Spe) were compared between the two sets; subgroup analyses according to the lesion's size were performed. Results: Regardless of lesion size, the respective Se and Spe of both datasets were not statistically different (95.7 and 100% vs. 76.1 and 94.6% for set-1 and -2 respectively; p = 0.18). For lesions larger than 35 mm, although both sets had similar specificity (100%), sensitivity was higher for SET-1 (100% vs. 40%); p = 0.04. Tumor classifications using SET-1 and SET-2 could have changed patient management in 35/54 (64.8%) and 33/54 (61.1%) of all patients, respectively. Conclusions: HBP-MRI or CEUS should be performed after an inconclusive CE-MRI. Both can change patient management by avoiding unnecessary biopsy or surveillance. The use of HBP-MRI should be advocated over CEUS in larger (>35 mm) lesions.
- Subjects
CONTRAST-enhanced ultrasound; GADOLINIUM isotopes; LIVER cancer; HYPERPLASIA treatment; ADENOMATOUS polyps; MAGNETIC resonance imaging
- Publication
Abdominal Radiology, 2017, Vol 42, Issue 3, p825
- ISSN
2366-004X
- Publication type
Article
- DOI
10.1007/s00261-016-0921-6