We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A Comprehensive Review on the Current Vaccines and Their Efficacies to Combat SARS-CoV-2 Variants.
- Authors
Rabaan, Ali A.; Mutair, Abbas Al; Hajissa, Khalid; Alfaraj, Amal H.; Al-Jishi, Jumana M.; Alhajri, Mashael; Alwarthan, Sara; Alsuliman, Shahab A.; Al-Najjar, Amal H.; Al Zaydani, Ibrahim A.; Al-Absi, Ghadeer Hassan; Alshaikh, Sana A.; Alkathlan, Mohammed S.; Almuthree, Souad A.; Alawfi, Abdulsalam; Alshengeti, Amer; Almubarak, Fatimah Z.; Qashgari, Mohammed S.; Abdalla, Areeg N. K.; Alhumaid, Saad
- Abstract
Since the first case of Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019, SARS-CoV-2 infection has affected many individuals worldwide. Eventually, some highly infectious mutants—caused by frequent genetic recombination—have been reported for SARS-CoV-2 that can potentially escape from the immune responses and induce long-term immunity, linked with a high mortality rate. In addition, several reports stated that vaccines designed for the SARS-CoV-2 wild-type variant have mixed responses against the variants of concern (VOCs) and variants of interest (VOIs) in the human population. These results advocate the designing and development of a panvaccine with the potential to neutralize all the possible emerging variants of SARS-CoV-2. In this context, recent discoveries suggest the design of SARS-CoV-2 panvaccines using nanotechnology, siRNA, antibodies or CRISPR-Cas platforms. Thereof, the present comprehensive review summarizes the current vaccine design approaches against SARS-CoV-2 infection, the role of genetic mutations in the emergence of new viral variants, the efficacy of existing vaccines in limiting the infection of emerging SARS-CoV-2 variants, and efforts or challenges in designing SARS panvaccines.
- Subjects
SARS-CoV-2; CORONAVIRUS diseases; VACCINE effectiveness; COVID-19
- Publication
Vaccines, 2022, Vol 10, Issue 10, pN.PAG
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines10101655