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- Title
Polymorphisms in the VEGF- A in polypoidal choroidal vasculopathy in a Korean population.
- Authors
Park, Dong; Kim, In
- Abstract
Purpose: The aim of this study was to investigate whether polymorphisms in the vascular endothelial growth factor A gene ( VEGF- A) are associated with polypoidal choroidal vasculopathy (PCV) in a Korean population and whether they are associated with PCV phenotypes. Methods: This was a case-control study comprising 111 patients with PCV and 123 control participants. The PCV and control groups were genotyped for five polymorphisms in VEGF- A. Clinical characteristics were evaluated, including best-corrected visual acuity, fundus findings, and angiography findings at the first visit. Main outcome measures were the genotypes of variants and association with phenotypes. Results: Only rs833069 in VEGF- A generated significant allelic associations with PCV ( P = 2.24 × 10). As compared with the AA group, the GG genotype group in rs833069 had a 6.25-fold increased risk of PCV [ P = 7.45 × 10, 95% confidence interval (CI) 2.52-15.46] and the AG group had a 1.82-fold increased risk ( P = 0.029, 95% CI 1.03-3.24). The haplotype CCGC in VEGF- A showed an association with PCV ( P = 2.90 × 10). However, the phenotypic characteristics of PCV did not show an association with the rs833069 genotypes. Conclusions: The rs833069 polymorphism in VEGF- A was significantly associated with the risk of PCV in a Korean population.
- Subjects
SOUTH Korea; VASCULAR endothelial growth factors; GROWTH factors; VISUAL acuity; VISION; VISUAL perception
- Publication
Japanese Journal of Ophthalmology, 2012, Vol 56, Issue 2, p145
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-012-0119-6