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- Title
Synthesis and Characterization of a Novel PAA Carrier for Apitoxin of Apis mellifera L.
- Authors
Deef, Karim O.; Helmy, Hanan; Barakat, Emad M. S.; Lotfy, Nadia M.; El Gohary, El Gohary E.
- Abstract
The current study aimed to characterize a novel bee venom -loaded polyacrylic acid carrier intended for cancer therapy. Honey bee venom was collected by the electric shock method. Poly acrylic acid and venom-loaded polyacrylic acid were prepared using potassium peroxodisulfate as an initiator. Nanoformulation was achieved by emulsion-solvent diffusion. Characterization was achieved by FT-IR, 1H-NMR, TEM, DFED, and UV spectrophotometry. TEM showed that the resultant spherical nanoparticles were either dispersed or in a nodular form and their diameter was 17-210 nm. DFED showed that the resultant nanoparticles did not show crystalline edges. FTIR and 1H-NMR concluded that there was no marked interaction between drug and selected polymer except in the physical encapsulation process. UV spectrophotometry indicated a 95% uniformity of drug content in the resultant nanoparticles. The study concluded that the PAA carrier may be a promising suitable carrier for bee venom.
- Subjects
HONEYBEES; BEE venom; ULTRAVIOLET spectrophotometry; POLYACRYLIC acid; ELECTRIC shock; NANOMEDICINE; ACRYLIC acid
- Publication
Egyptian Academic Journal of Biological Sciences. A, Entomology, 2020, Vol 13, Issue 1, p155
- ISSN
1687-8809
- Publication type
Article
- DOI
10.21608/eajbsa.2020.76598