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- Title
骨胶原肽对老年骨质疏松症患者骨密度和骨代谢指标的影响.
- Authors
田雨佳; 韩岩峰; 宋瑛世; 徐静波; 刘巍
- Abstract
Objective To investigate the effects of bone collagen peptide combined with alendronate on bone mineral density and bone metabolism in elderly patients with osteoporosis. Methods 138 elderly patients with osteoporosis were randomly divided into treatment group and control group, with 69 cases in each group. Patients in the control group were treated with alendronate, and patients in the treatment group were treated with collagen-peptide combined with alendronate for 12 months. BMD of lumbar anteroposterior(L1-4) and left femoral neck, bone alkaline phosphatase(BALP) and tartrate-resistant acid phosphatase-5 b(TRAP-5 b) levels were examined before treatment and after 12 months of treatmentas and treatment efficiency and adverse reactions were recorded in the two groups. Results After 12 months of treatment, patients in the treatment group had significantly higher lumbar spine(L1-4) and left femoral neck BMD than those in the control group(P<0.05). After 12 months of treatment, serum BALP and serum phosphorus levels in the two groups were significantly lower than those before treatment, serum TRAP-5 b and serum calcium levels were significantly higher than those before treatment, both of statistical significance(P<0.05), and the treatment group had greater improvement than the control group(P<0.05). The effective rate of treatment in the treatment group was better than that in the control group(P <0.05), and there was no significant difference in adverse reactions between the two groups(P>0.05). Conclusion Collagen peptide combined with alendronate sodium could safely and effectively improve bone mineral density and improve bone metabolism in elderly osteoporosis patients.
- Publication
Chinese Journal of Osteoporosis, 2019, Vol 25, Issue 10, p1425
- ISSN
1006-7108
- Publication type
Article
- DOI
10.3969/j.issn.1006-7108.2019.10.012