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- Title
Efficacy of zoledronic acid in the treatment of elderly women with osteoporotic fractures.
- Authors
LI Zutao; SUN Jungang; XV Wanlong; MIAO Xiaogang; XV Jiangbo; YUAN Hong
- Abstract
Objective To study the curative effect of zoledronic acid on osteoporotic fractures in elder women. Methods A total of 192 patients, aging over 60 years, with osteoporotic fractures were enrolled and assigned into 2 groups from 2009 to 2010.Patients in both groups received Caltratc D and Calcitriol while receiving fracture treatment. Patients in the treatment group received 5 mg zoledronic acid infusion 1-2 weeks after the operation. Bone mineral density (BMD) of the lumbar spine was measured using dual-energy X-ray absorptiometry (DXA) every 12 months after the operation. Fracture healing and the rate of second fractures in 3 years were also observed. Results The BMD in treatment group was significantly higher than in control group (P < 0.05) in the 3-year treatment period. The rate of second fractures in treatment group was obviously lower than in control group, with statistical significance (P < 0.05). And the fractures healed well in both groups within 3-month follow-up. Conclusion Zolcdronic acid can significantly reduce the rate of second fractures, improve BMD in elderly women, with no influence in the fracture healing
- Publication
Chinese Journal of Osteoporosis, 2014, Vol 20, Issue 10, p1233
- ISSN
1006-7108
- Publication type
Article