We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Anti-inflammatory effect of l-cysteine (a semi-essential amino acid) on 5-FU-induced oral mucositis in hamsters.
- Authors
Fonseca, Khetyma Moreira; Macda RodriguesCosta, Dionys; da Silva, Valderlon Freitas; de Carvalho, Jelson Lina; Oliveira, Ana Patrícia; de Melo Sousa, Francisca Beatriz; Lopes, André Luis Fernandes; da Silva Martins, Conceição; de Sousa Chaves, Letícia; Nicolau, Lucas Antonio Duarte; Cerqueira, Gilberto Santos; Medeiros, Jand Venes Rolim
- Abstract
Oral mucositis is an inflammation of the oral mucosa mainly resulting from the cytotoxic effect of 5-fluorouracil (5-FU). The literature shows anti-inflammatory action of l-cysteine (l-cys) involving hydrogen sulfide (H2S). In view of these properties, we investigate the effect of l-cys in oral mucositis induced by 5-FU in hamsters. The animals were divided into the following groups: saline 0.9%, mechanical trauma, 5-FU 60–40 mg/kg, l-cys 10/40 mg and NaHS 27 µg/kg. 5-FU was administered on days 1st to 2nd; 4th day excoriations were made on the mucosa; 5th–6th received l-cys and NaHS. For data analysis, histological analyses, mast cell count, inflammatory and antioxidants markers, and immunohistochemistry (cyclooxygenase-2(COX-2)/inducible nitric oxide synthase (iNOs)/H2S) were performed. Results showed that l-cys decreased levels of inflammatory markers, mast cells, levels of COX-2, iNOS and increased levels of antioxidants markers and H2S when compared to the group 5-FU (p < 0.005). It is suggested that l-cys increases the H2S production with anti-inflammatory action in the 5-FU lesion.
- Subjects
NITRIC-oxide synthases; AMINO acids; HAMSTERS; MUCOSITIS; ORAL mucosa; CYSTEINE; LIPOXINS
- Publication
Amino Acids, 2021, Vol 53, Issue 9, p1415
- ISSN
0939-4451
- Publication type
Article
- DOI
10.1007/s00726-021-03062-z