We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
DAMP molecules S100A9 and S100A8 activated by IL-17A and house-dust mites are increased in atopic dermatitis.
- Authors
Jin, Shan; Park, Chang Ook; Shin, Jung U; Noh, Ji Yeon; Lee, Yun Sun; Lee, Na Ra; Kim, Hye Ran; Noh, Seongmin; Lee, Young; Lee, Jeung‑Hoon; Lee, Kwang Hoon
- Abstract
S100A9 and S100A8 are called damage-associated molecular pattern (DAMP) molecules because of their pro-inflammatory properties. Few studies have evaluated S100A9 and S100A8 function as DAMP molecules in atopic dermatitis (AD). We investigated how house-dust mites affect S100A9 and S100A8 expression in Th2 cytokine- and Th17 cytokine-treated keratinocytes, and how secretion of these molecules affects keratinocyte-derived cytokines. Finally, we evaluated expression of these DAMP molecules in AD patients. S100A9 expression and S100A8 expression were strongly induced in IL-17A- and Dermatophagoides ( D.) farinae-treated keratinocytes, respectively. Furthermore, co-treatment with D. farinae and IL-17A strongly increased expression of S100A9 and S100A8 compared with D. farinae-Th2 cytokine co-treatment. The IL-33 mRNA level increased in a dose-dependent manner in S100A9-treated keratinocytes, but TSLP expression did not change. S100A8/A9 levels were also higher in the lesional skin and serum of AD patients, and correlated with disease severity. Taken together, S100A9 and S100A8 may be involved in inducing DAMP-mediated inflammation in AD triggered by IL-17A and house-dust mites.
- Subjects
DERMATOPHAGOIDES pteronyssinus; ATOPIC dermatitis; SKIN inflammation; INTERLEUKIN-17; THERAPEUTIC use of cytokines; KERATINOCYTES
- Publication
Experimental Dermatology, 2014, Vol 23, Issue 12, p938
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/exd.12563