We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
miR-98-5p plays a critical role in depression and antidepressant effect of ketamine.
- Authors
Huang, Chaoli; Wang, Yuanyuan; Wu, Zifeng; Xu, Jiali; Zhou, Ling; Wang, Di; Yang, Ling; Zhu, Bin; Chen, Guiquan; Liu, Cunming; Yang, Chun
- Abstract
Ketamine has been demonstrated to be a rapid-onset and long-lasting antidepressant, but its underlying molecular mechanisms remain unclear. Recent studies have emerged microRNAs as important modulators for depression treatment. In this study, we report that miR-98-5p is downregulated in the prefrontal cortex and hippocampus of mice subjected to chronic social stress, while overexpressing it by its agonist alleviates depression-like behaviors. More importantly, we demonstrate that miR-98-5p is upregulated by ketamine administration, while inhibition of it by its antagonist blocks the antidepressant effect of ketamine. Our data implicate a novel molecular mechanism underlying the antidepressant effect of ketamine, and that therapeutic strategies targeting miR-98-5p could exert beneficial effects for depression treatment.
- Publication
Translational Psychiatry, 2021, Vol 11, Issue 1, p1
- ISSN
2158-3188
- Publication type
Article
- DOI
10.1038/s41398-021-01588-0