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- Title
Gender differences in response to vitamin E and C in gentamicin induced nephrotoxicity in Wistar rats.
- Authors
Safari, Tahereh; Nematbakhsh, Mehdi; Miri, Saideh; Ghofran, Omid; Fereidooni, Fatemeh; Niazi, Abbass Ali; Bagheri, Hossein
- Abstract
Background: Nephrotoxicity is the most recognized side effect of gentamicin. Vitamin E and vitamin C demonstrate their effective role in the prevention of nephrotoxicity. Likewise, previous studies have suggested that women have low risk of end-stage renal disease at premenopausal period. Objectives: This study aims to investigate the possibility of any gender difference in response to antioxidant effects vitamins E and C in gentamicin-induced nephrotoxicity. Materials and Methods: Wistar rats were randomly assigned to 6 groups each including both male and female rats. The first and second groups received saline (control group) and almond oil, the third group received gentamicin. The fourth group received a regular dose of gentamicin + vitamin E. Similarly, the fifth group received a regular dose of gentamicin + vitamin C. The sixth group received a dose of gentamicin + vitamin C and E simultaneously constantly. This protocol continued for 9 days. Results: Gentamicin increased significantly urea, creatinine (Cr) and malondialdehyde (MDA), but it decreased superoxidase dismutase (SOD) level (P < 0.05). Treatment with antioxidant vitamins improved urea, creatinine, MDA, and SOD serum level significantly in both genders (P <0.05). Likewise, kidney MDA level enhanced significantly (P <0.05) and treatment with antioxidant vitamins reduced MDA level too (P <0.05). Gentamicin decreased kidney SOD activity in male and female rats (P <0.05). However, treatment with antioxidant vitamins did not improve its level in male rats, while in female rats, vitamins E and C compensated for kidney SOD activity. Conclusions: Antioxidant vitamins modified gentamicin-induced nephrotoxicity in both genders, with some difference in response to vitamins E and C between the genders, that was higher in female rats.
- Subjects
NEPHROTOXICOLOGY; VITAMIN therapy; GENTAMICIN; PREVENTION
- Publication
Journal of Nephropathology, 2017, Vol 6, Issue 4, p338
- ISSN
2251-8363
- Publication type
Article
- DOI
10.15171/jnp.2017.54