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- Title
PECTIN MICROGELS CONTAINING SYNTHETIC POLYMERS BASED ON NANOCAPSULES FOR THE CONTROLLED RELEASE OF INDOMETHACIN.
- Authors
HOLBAN, Mihaela; FOLESCU, Elena; SACHELARIE, Liliana; MERLUŞCĂ, Paula; ROTARU, Adina Simona; VASILIU, Mihaela; DÂRŢU, Laura
- Abstract
Nanocapsule-based Eudragit RS100 and Eudragit E100 containing indomethacin have been prepared. The nanosuspensions have been included into pectin microgels of different polysaccharide concentrations, 28-61 μm-ranged polymer microgels with size and size polydispersity highly depending on the pectin amount being thus obtained. Study of the drug release revealed that indomethacin was released at a slower and more controlled rate from the microgels containing nanocapsules than from the empty pectin microgels. Also, the rate of released indomethacin increased with the augmentation of pectin amount into the microgels.
- Subjects
INDOMETHACIN; ANTIARTHRITIC agents; MICROGELS
- Publication
International Journal of Medical Dentistry, 2015, Vol 19, Issue 4, p265
- ISSN
2066-6063
- Publication type
Article