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- Title
CD9 Gene Variations Are Not Associated with Female Infertility in Humans.
- Authors
Nishiyama, Sachie; Kishi, Taro; Kato, Takema; Suzuki, Machiko; Nishizawa, Haruki; Pryor-Koishi, Kanako; Sawada, Tomio; Nishiyama, Yukio; Iwata, Nakao; Udagawa, Yasuhiro; Kurahashi, Hiroki
- Abstract
Background/Aims: To determine whether genetic alterations in the CD9 gene are associated with female infertility in humans. Methods: We sequenced the entire coding region of this gene in 86 Japanese women with unexplained infertility and further conducted a case-control study of six tagging single nucleotide polymorphisms (SNPs) in this gene using an additional 164 samples obtained from a fertile control group. Results: No disease-causing mutation in the CD9 gene was evident in these samples and no significant association between the tagging SNPs and the studied cohort was identified. Conclusions: Our findings do not support the hypothesis that genetic alterations of the CD9 gene cause female infertility in humans. Copyright © 2009 S. Karger AG, Basel
- Subjects
INFERTILITY; NUCLEOTIDES; GENETIC polymorphisms; JAPANESE people; DISEASES in women
- Publication
Gynecologic & Obstetric Investigation, 2010, Vol 69, Issue 2, p116
- ISSN
0378-7346
- Publication type
Article
- DOI
10.1159/000262451