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- Title
Assessment of primary haemostasis with a new recombinant von Willebrand factor in patients with von Willebrand disease.
- Authors
Trossaërt, Marc; Flaujac, Claire; Jeanpierre, Emmanuelle; Drillaud, Nicolas; Sigaud, Marianne; Fouassier, Marc; Ternisien, Catherine; de Raucourt, Emmanuelle
- Abstract
The multimeric composition of the von Willebrand factor (VWF) is essential to its function, especially for platelet adhesion to the site of vascular injury, with high molecular weight multimers (HMWM) being the most active. Patient 1 is a 49-year-old patient with type 3 VWD (FVIII:C 2 IU/dL; VWF:GPIbR and VWF:Ag < 1 IU/) confirmed by molecular biology (double heterozygosity for nonsense mutations: p.Ser2079X and p.Arg2535X).
- Subjects
VON Willebrand factor; VON Willebrand disease; HEMOSTASIS
- Publication
Haemophilia, 2020, Vol 26, Issue 2, pe44
- ISSN
1351-8216
- Publication type
Article
- DOI
10.1111/hae.13916