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- Title
Maternal BMI and Glycemia Impact the Fetal Metabolome.
- Authors
Lowe Jr., William L.; Bain, James R.; Nodzenski, Michael; Reisetter, Anna C.; Muehlbauer, Michael J.; Stevens, Robert D.; Ilkayeva, Olga R.; Lowe, Lynn P.; Metzger, Boyd E.; Newgard, Christopher B.; Scholtens, Denise M.; Lowe, William L Jr; HAPO Study Cooperative Research Group
- Abstract
<bold>Objective: </bold>We used targeted metabolomics to determine associations of maternal BMI and glucose levels with cord blood metabolites and associations of cord blood metabolites with newborn birth weight and adiposity in mother-offspring dyads.<bold>Research Design and Methods: </bold>Targeted metabolomic assays were performed on cord blood serum samples from European ancestry, Afro-Caribbean, Thai, and Mexican American newborns (400 from each ancestry group) whose mothers participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and who had anthropometric measurements at birth.<bold>Results: </bold>Meta-analysis across the four cohorts demonstrated significant correlation of all cord blood metabolites analyzed with maternal fasting levels of the same metabolites at ∼28 weeks' gestation except for triglycerides, asparagine/aspartate, arginine, and the acylcarnitine C14-OH/C12-DC. Meta-analyses also demonstrated that maternal BMI with or without adjustment for maternal glucose was associated with cord blood metabolites including the branched-chain amino acids and their metabolites as well as phenylalanine. One-hour but not fasting glucose was associated with cord blood 3-hydroxybutyrate and its carnitine ester, a medium-chain acylcarnitine, and glycerol. A number of cord blood metabolites were associated with newborn birth weight and sum of skinfolds, including a negative association of triglycerides and positive association of 3-hydroxybutyrate, its carnitine ester, and serine with both newborn outcomes.<bold>Conclusions: </bold>Maternal BMI and glycemia are associated with different components of the newborn metabolome, consistent with their independent effects on newborn size at birth. Maternal BMI is associated with a newborn metabolic signature characteristic of insulin resistance and risk of type 2 diabetes in adults.
- Subjects
METABOLOMICS; BODY mass index; GLUCOSE; METABOLITES; NEWBORN infant health; ADIPOSE tissues; BIOCHEMISTRY; BIRTH weight; BLOOD sugar; HUMAN body composition; BRANCHED chain amino acids; ETHNIC groups; CORD blood; GLUCOSE tolerance tests; INSULIN resistance; LONGITUDINAL method; META-analysis; METABOLISM; TYPE 2 diabetes; OBESITY; PHENYLALANINE; QUESTIONNAIRES; REGRESSION analysis; TRIGLYCERIDES; 3-Hydroxybutyric acid; PRENATAL exposure delayed effects; IMPACT of Event Scale
- Publication
Diabetes Care, 2017, Vol 40, Issue 7, p902
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc16-2452