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- Title
External validation of pharmacokinetic and pharmacodynamic models of microemulsion and long-chain triglyceride emulsion propofol in beagle dogs.
- Authors
LEE, S. -H.; PARK, H. -W.; KIM, M. -J.; NOH, M. -H.; YOON, H. -S.; CHOI, B. -M.; LEE, E. -K.; NOH, G. -J.
- Abstract
Lee, S.-H., Park, H.-W., Kim, M.-J., Noh, M.-H., Yoon, H.-S., Choi, B.-M., Lee, E.-K., Noh, G.-J. External validation of pharmacokinetic and pharmacodynamic models of microemulsion and long-chain triglyceride emulsion propofol in beagle dogs. J. vet. Pharmacol. Therap. 35, 329-341. This study aimed at assessing the predictive performance of a target-controlled infusion (TCI) system, which incorporates canine PK-PD models for microemulsion and long-chain triglyceride emulsion (LCT) propofol and at investigating time independency of propofol effect on the observed electroencephalographic approximate entropy (ApEn) in TCI. Using a crossover design with a 7-day washout period, 28 healthy beagle dogs were randomized to receive TCI of both formulations in a stepwise or constant manner. Plasma propofol concentrations and ApEn were measured at preset intervals. Pooled biases, inaccuracies, divergences, and wobbles in pharmacokinetic and pharmacodynamic predictions were 2.1% (95% CI: −0.8 to 4.9), 18.1% (15.6-20.5), 1.9%/h, 7.3% (5.4-9.3), and −0.5% (−2.6 to 1.6), 8.7% (7.3-10.1), 2.5%/h, 6.0% (4.1-7.2) for microemulsion propofol, and −9.3% (−11.6 to −6.9), 20.1% (18.2-22.0), 5.1%/h, 7.6% (6.1-9.1) and 5.6% (4.1-7.1), 8.0% (6.9-9.3), 4.7%/h, 4.1% (3.1-5.1) for LCT propofol. Observed ApEn values over time were statistically not different across all time points in a TCI with constant manner. Canine PK-PD model of microemulsion propofol showed good predictive performances. Propofol effect (ApEn) was time independent as long as time is allowed for equilibration.
- Subjects
PHARMACOKINETICS; PHARMACODYNAMICS; MICROEMULSIONS; TRIGLYCERIDES; PROPOFOL; BEAGLE (Dog breed)
- Publication
Journal of Veterinary Pharmacology & Therapeutics, 2012, Vol 35, Issue 4, p329
- ISSN
0140-7783
- Publication type
Article
- DOI
10.1111/j.1365-2885.2011.01321.x