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- Title
Molecular Dynamics Investigation of Lipid-Specific Interactions with a Fusion Peptide.
- Authors
Heller, William T.
- Abstract
The HIV-1 fusion peptide, which is a short hydrophobic peptide from the gp41 coat glycoprotein that participates in the infection of a cell, interacts with model lipid bilayer membranes in a concentration-dependent manner. The interaction of the peptide with the bilayer also strongly depends on the lipid composition. Here, molecular dynamics simulations were performed to investigate lipid-specific interactions that arise shortly after the binding of a less-fusogenic variant of the HIV-1 fusion peptide to a lipid bilayer composed of a mixture of dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol. The impact of peptide concentration was also studied. An improved understanding was gained of the lipid-specific interactions experienced by the FP. New insight was also gained into how the peptide concentration changes these interactions.
- Subjects
PEPTIDES; BILAYER lipid membranes; MOLECULAR dynamics; COAT proteins (Viruses)
- Publication
Biomolecules (2218-273X), 2024, Vol 14, Issue 3, p285
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom14030285