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- Title
Multiple Origins of Foot-and-Mouth Disease Virus Serotype Asia 1 Outbreaks, 2003-2007.
- Authors
Valarcher, Jean-Francois; Knowles, Nick J.; Zakharov, Valery; Scherbakov, Alexey; Zhang, Zhidong; Shang, You-Jun; Liu, Zai-Xin; Liu, Xiang-Tao; Sanyal, Aniket; Hemadri, Divakar; Tosh, Chakradhar; Rasool, Thaha J.; Pattnaik, Bramhadev; Schumann, Kate R.; Beckham, Tammy R.; Wilai Linchongsubongkoch; Ferris, Nigel P.; Roeder, Peter L.; Paton, David J.
- Abstract
We investigated the molecular epidemiology of foot-and- mouth disease virus (FMDV) serotype Asia 1, which caused outbreaks of disease in Asia during 2003-2007. Since 2004, the region affected by outbreaks of this serotype has increased from disease-endemic countries in southern Asia (Afghanistan, India, Iran, Nepal, Pakistan) northward to encompass Kyrgyzstan, Tajikistan, Uzbekistan, several regions of the People's Republic of China, Mongolia, Eastern Russia, and North Korea. Phylogenetic analysis of complete virus capsid protein 1 (VP1) gene sequences demonstrated that the FMDV isolates responsible for these outbreaks belonged to 6 groups within the Asia 1 serotype. Some contemporary strains were genetically closely related to isolates collected historically from the region as far back as 25 years ago. Our analyses also indicated that some viruses have spread large distances between countries in Asia within a short time.
- Subjects
ASIA; MOLECULAR epidemiology; FOOT &; mouth disease epidemiology; FOOT &; mouth disease virus; MIRIDAE; SEROTYPES
- Publication
Emerging Infectious Diseases, 2009, Vol 15, Issue 7, p1046
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid1507.081621