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- Title
Endothelium-Dependent Induction of Vasorelaxation by the Butanol Extract of Phellinus igniarius in Isolated Rat Aorta.
- Authors
Dae Gill Kang; Li Hua Cao; Jun Kyoung Lee; Deok Ho Choi; Seung Ju Kim; Hyuck Lee; Jin Sook Kim; Ho Sub Lee
- Abstract
The butanol extract of Phellinus igniarius (BPI) induced relaxation of the phenylephrin e-precontracted rat aorta in a dose-dependent manner, and its effect was abolished by the removal of functional endothelium. Pretreatment of the aortic tissues with NG-nitro-L-arginine methyl ester (L-NAME), methylene blue, or 1H-[1,2,4]-oxadiazole-[4,3-α]-quinoxalin1-one (ODQ) inhibited the vascular relaxation induced by BPI. BPI-induced vascular relaxations were also markedly attenuated by the addition of verapamil or diltiazem, while the relaxant effect of BPI was not blocked by pretreatment with indomethacine, glibenclamide, tetraethylammonium (TEA), atropine, or propranolol. Incubation of endothelium-intact rat aorta with BPI increased the production of cGMP in a dose-dependent manner. These results suggest that BPI dilates vascular smooth muscle via endothelium-dependent nitric oxide-cGMP signaling pathway, with the possible involvement of L-type Ca2+ channels.
- Subjects
BUTANOL; PLANT extracts; ENDOTHELIUM; GLIBENCLAMIDE; PROPRANOLOL; VASCULAR smooth muscle
- Publication
American Journal of Chinese Medicine, 2006, Vol 34, Issue 4, p655
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/S0192415X06004181