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- Title
Case Report: Multidisciplinary management of primary inferior vena cava leiomyosarcoma: a comprehensive case study.
- Authors
Wuchao Li; Xiaoyong Zhang; Yi Zhang; Rongpin Wang
- Abstract
Introduction: Primary Inferior vena cava (IVC) leiomyosarcoma, a rare malignant tumor, presents unique challenges in diagnosis and treatment due to its rarity and the lack of consensus on surgical and adjuvant therapy approaches. Case Report: A 39-year-old female patient presented with lower limb swelling and mild fatigue. Contrast-enhanced CT identified a tumor mass within the dilated IVC. AbdominalMRI revealed primary IVC leiomyosarcoma extending into the right hepatic vein. Amultidisciplinary consultation established a diagnosis and devised a treatment plan, opting for Ex-vivo Liver Resection and Auto- transplantation (ELRA), tumor resection and IVC reconstruction. Pathological examination confirmed primary IVC leiomyosarcoma. Postoperatively, the patient underwent a comprehensive treatment strategy that included radiochemotherapy, immunotherapy, targeted therapy, and PRaG therapy (PD- 1 inhibitor, Radiotherapy, and Granulocyte-macrophage colony-stimulating factor). Despite the tumor's recurrence and metastasis, the disease progression was partially controlled. Conclusion: This case report emphasizes the complexities of diagnosing and treating IVC leiomyosarcoma and highlights the potential benefits of employing ELRA, IVC reconstruction, and PRaG therapy. Our study may serve as a valuable reference for future investigations addressing the management of this rare disease.
- Subjects
VENA cava inferior; LEIOMYOSARCOMA; PULMONARY alveolar proteinosis; GRANULOCYTE-macrophage colony-stimulating factor; HEPATIC veins; CANCER relapse; TUMOR surgery
- Publication
Frontiers in Oncology, 2023, p01
- ISSN
2234-943X
- Publication type
Article
- DOI
10.3389/fonc.2023.1190276