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- Title
Evaluation of vitamin D status and its correlation with gonadal function in children at mini‐puberty.
- Authors
Kılınç, Suna; Atay, Enver; Ceran, Ömer; Atay, Zeynep
- Abstract
Summary: Context: The effects of Vitamin D on reproductive function in adults have gained interest. Studies have demonstrated some associations. Hypothalamic‐pituitary‐gonadal axis is activated during the first 6 months of life, called as mini‐puberty. This HPG activation is important for future gonadal function. There are no data regarding the association of gonadal hormones and 25(OH)D levels at mini‐puberty. Demonstration of any association would form the basis for studies that will search for the effects of 25(OH)D on gonadal hormones at mini‐puberty. Objective: To characterize the associations between 25(OH)D levels and gonadal hormones at mini‐puberty. Design: Cross‐sectional cohort analysis. Patient(s) or other participant(s): A total of 180 (94 boys and 86 girls) healthy appropriate‐for‐gestational‐age neonates were included. Main outcome measure(s): 25(OH)D, LH, FSH, total testosterone, oestradiol, AMH and inhibin B levels were measured at postnatal 30‐45 days. All infants were divided into three groups including vitamin D deficiency (<10 ng/mL), vitamin D insufficiency (10‐20 ng/mL) and vitamin D sufficiency (>20 ng/mL). Correlations between vitamin D status and reproductive hormones were analysed. Result(s): Total testosterone level was higher (mean: 0.52 ± 0.32 vs 0.26 ± 0.2 ng/mL; P: 0.008) and inhibin B was lower in 25(OH)D deficient than sufficient girls (mean: 21.2 ± 15.71 vs 53.25 ± 47.25 pg/mL; P: 0.021). Conclusion(s): A modest effect of 25(OH)D was identified on total testosterone and inhibin B in girls at mini‐puberty. The 25(OH)D may have an effect on gonadal function during early life. Randomized controlled trials could clarify the importance of vitamin D on gonadal hormones at mini‐puberty.
- Subjects
VITAMIN D; CALCIUM regulating hormones; STEROID hormones; GONADAL diseases; DELAYED puberty; ENDOCRINOLOGY
- Publication
Clinical Endocrinology, 2019, Vol 90, Issue 1, p122
- ISSN
0300-0664
- Publication type
Article
- DOI
10.1111/cen.13856