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- Title
Alcohol-Associated Liver Disease: Evolving Concepts and Treatments.
- Authors
Prince, David Stephen; Nash, Emily; Liu, Ken
- Abstract
Alcohol is a prominent cause of liver disease worldwide with higher prevalence in developed nations. The spectrum of alcohol-associated liver disease (ALD) encompasses a diverse range of clinical entities, from asymptomatic isolated steatosis to decompensated cirrhosis, and in some cases, acute or chronic liver failure. Consequently, it is important for healthcare practitioners to maintain awareness and systematically screen for ALD. The optimal evaluation and management of ALD necessitates a collaborative approach, incorporating a multidisciplinary team and accounting for concurrent medical conditions. A repertoire of therapeutic interventions exists to support patients in achieving alcohol cessation and sustaining remission, with complete abstinence being the ultimate objective. This review explores the existing therapeutic options for ALD acknowledging geographical discrepancies in accessibility. Recent innovations, including the inclusion of alcohol consumption biomarkers into clinical protocols and the expansion of liver transplantation eligibility to encompass severe alcohol-associated hepatitis, are explored.
- Subjects
THERAPEUTICS; BIOMARKERS; ALCOHOLIC liver diseases; DISEASES; TEMPERANCE; ALCOHOL drinking; HEALTH care teams; LIVER transplantation; SYMPTOMS; DISEASE complications; DEVELOPED countries
- Publication
Drugs, 2023, Vol 83, Issue 16, p1459
- ISSN
0012-6667
- Publication type
Article
- DOI
10.1007/s40265-023-01939-9