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- Title
GC/MS analysis of aqueous ethanol solutions of drugs. Part 1. Menthol and p-aminobenzoic acid derivatives.
- Authors
Ermakov, A. I.; Khomyakov, Yu. Yu.; Soshenko, L. P.; Plyushchikov, V. G.
- Abstract
Ajoint GC/MS analysis of aqueous and aqueous-ethanol solutions of some drugs including menthol, validol, benzocaine, novocaine, and menovazin has been performed using a Varian 3900/2100T (USA) instrument equipped with a Varian Factor Four VF-5ms capillary column. The structures of some impurities that were previously based on theoretical considerations are confirmed. Structural-analytical possibilities of the latest modification of the Varian GC/MS system with an ion-trap source are investigated. It is possible to obtain clear mass spectra even for low-intensity and partly overlapping chromatographic peaks using the given device combination. The results can be used for quality control of drugs based on the investigated compounds.
- Subjects
DRUGS; ALCOHOL; QUALITY control; VARIAN Inc.; MEDICAL equipment
- Publication
Pharmaceutical Chemistry Journal, 2009, Vol 43, Issue 8, p480
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-009-0328-6