We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Dengue virus-reactive CD8<sup>+</sup> T cells mediate cross-protection against subsequent Zika virus challenge.
- Authors
Ngono, Annie Elong; Regla-Nava, Jose Angel; Kim, Kenneth; Jinsheng Wen; Shresta, Sujan; Gorman, Matthew J.; Diamond, Michael S.
- Abstract
Zika virus (ZIKV) and dengue virus (DENV) are antigenically related flaviviruses that share cross-reactivity in antibody and T cell responses, and co-circulate in increasing numbers of countries. Whether pre-existing DENV immunity can cross-protect or enhance ZIKV infection during sequential infection of the same host is unknown. Here, we show that DENV-immune Ifnar1−/− or wild-type C57BL/6 mice infected with ZIKV have cross-reactive immunity to subsequent ZIKV infection and pathogenesis. Adoptive transfer and cell depletion studies demonstrate that DENV-immune CD8+ T cells predominantly mediate cross-protective responses to ZIKV. In contrast, passive transfer studies suggest that DENV-immune serum does not protect against ZIKV infection. Thus, CD8+ T cell immunity generated during primary DENV infection can confer protection against secondary ZIKV infection in mice. Further optimization of current DENV vaccines for T cell responses might confer cross-protection and prevent antibody-mediated enhancement of ZIKV infection.
- Subjects
ZIKA virus; DENGUE viruses; T cells; IMMUNITY; IMMUNOGLOBULINS
- Publication
Nature Communications, 2017, Vol 8, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-017-01669-z