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- Title
PROSPECTS FOR COMBINING T-CELL TARGETED & CONVENTIONAL CANCER THERAPY WITH IMMUNOTHERAPY.
- Authors
Namdev, Juhi; Saraogi, Gourav k.; Singhai, A. K.
- Abstract
There has been significant progress in utilizing our immune system against cancer, mainly by checkpoint blockade and T cell-mediated therapies. The field of cancer immunotherapy is growing rapidly but durable clinical benefits occur only in a small subset of responding patients. Cancer creates a suppressive metabolic microenvironment, which contributes to ineffective immune function. Metabolism is a common cellular feature, and has significant progress in role of metabolic changes of the tumor microenvironment (TEM) in immune cells. We are highlight the importance of metabolism on the function of tumor-associated immune cells and will address the role of key metabolic determinants that might be targets of therapeutic intervention for improvement of tumor immunotherapies and mechanisms of protective tumour immunity has several therapeutic strategies most notably the 'immune checkpoint' antibodies that reverse the negative regulators of T cell function targeted and immune-based therapies. Additional insights into the effects of targeted therapies, along with conventional chemotherapy and radiation therapy, on the induction of immunity will help to advance the design of combination strategies that increase the rate of complete and durable clinical response in patients and that might be targets of therapeutic intervention for improvement of cancer.
- Subjects
CANCER treatment; IMMUNOTHERAPY; CELL metabolism; CELL physiology; TUMOR microenvironment; T cells
- Publication
International Journal of Pharmacy & Life Sciences, 2019, Vol 10, Issue 6, p78
- ISSN
0976-7126
- Publication type
Article