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- Title
ALTERNATIVE TO ANIMAL SCREENING METHODS IN DRUG RESEARCH: BENEFITS BEYOND MEASURE.
- Authors
Soni, Love Kumar
- Abstract
The increase in the number of animals used in the drug research by CROs and pharmaceutical research organizations alarmed the researchers to find the alternative to the animal screening methods used in drug research. The animal used in drug research suffers from pain and distress which also results in death of the experimental animal. This is also a debatable issue for the animal welfare organizations. In the recent year the understanding of the drug function at cellular and molecular level has increased due to the advances in the biological sciences and medicinal chemistry. The advent of the computer aided drug design techniques makes it easy to get an insight into the structural and molecular requirements influencing the biological activity of the drugs. With the methods like Virtual screening, also known as in silico screening, represents a fast and cost effective tool for screening several thousand compounds in search for novel drug leads and to identify the compounds which are most likely to be active so that the structures would be given priority for actual animal screening. Advance techniques like docking to carry out the virtual screening can be seen as complementary to biological screening to identify the molecules from a chemical library that are most likely to bind to the target. These can then be given priority for biological screening making the biological screening more efficient.
- Subjects
PHARMACEUTICAL research; DRUG use testing; PHARMACODYNAMICS; PSYCHOLOGICAL distress; ANIMAL welfare; ANIMAL models in research
- Publication
International Journal of Pharmacy & Life Sciences, 2016, Vol 7, Issue 9, p3
- ISSN
0976-7126
- Publication type
Article