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- Title
Evaluation of antimicrobial activity of curcuminoids isolated from turmeric.
- Authors
Singh, Rana Pratap; Jain, D. A.
- Abstract
In a search for plant extracts with potent antimicrobial activity, turmeric (Curcuma longa) was extracted to get volatile oil and total curcuminoids .Further total curcuminoids portion was isolated by column chromatography to get curcumin , bisdemethoxycurcumin and demethoxycurcumin. The isolated curcuminoids were identified and characterized by melting point, thin layer chromatography, infra red spectroscopy, nuclear magnetic resonance and mass spectrometry. All the three isolated curcuminoids were evaluated for antibacterial activity by Agar diffusion method against medically important bacteria viz. B. subtilis, K. pneumonia, E. coli, Enterobacter aerogenes, Pseudomonas aeruginosa, S. auresus and P. Mirabilis. Two fungi were selected viz. Aspergillus niger and Candida albicans for antifungal potential of three isolated curcuminoids by Agar well diffusion method. Out of three curcuminoids, curcumin showed better antibacterial as well as antifungal activity as compare to bisdemethoxycurcumin and demethoxycurcumin. Kanamycin was used as standard drug for antibacterial activity and Fluconazole as standard for antifungal activity.
- Subjects
TURMERIC; ESSENTIAL oils; CHROMATOGRAPHIC analysis; INFRARED spectroscopy; NUCLEAR magnetic resonance; MASS spectrometry
- Publication
International Journal of Pharmacy & Life Sciences, 2012, Vol 3, Issue 1, p1368
- ISSN
0976-7126
- Publication type
Article