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- Title
Cyclin D1 Expression in Salivary Gland Tumors: An Immunohistochemical Analysis.
- Authors
Moghadam, Saede Atarbashi; Jahani, Neda; Mokhtari, Sepideh
- Abstract
Background: Gene amplification and over-expression of Cyclin D1 have been frequently demonstrated in many malignant tumors. The alterations in Cyclin D1 expression by immunohistochemical methods in salivary gland tumors have shown conflicting data concerning the molecular events involved in the salivary gland tumors. Hence the present study was performed to evaluate Cyclin D1 expression in salivary gland neoplasms. Method and Materials: Tissue specimens of 15 pleomorphic adenoma and 15 malignant salivary gland tumors including mucoepidermoid carcinoma, adenoid cystic carcinoma and salivary duct carcinoma were examined by immunohistochemistry for Cyclin D1 protein. Cyclin D1 expression was evaluated based on the percentage of nuclei expressing this protein in any intensity. Results: Twenty-five specimens (83.3%) were negative for this marker and only three pleomorphic adenomas and two adenoid cystic carcinomas were positive (16.6%). There was no significant difference between benign and malignant salivary gland tumors. Conclusion: Overexpression of Cyclin D1 probably does not play a role in pathogenesis of benign and malignant salivary gland tumors.
- Subjects
GENE amplification; SALIVARY gland tumors; CYCLINS
- Publication
International Journal of Oral & Maxillofacial Pathology, 2016, Vol 7, Issue 1, p2
- ISSN
2231-2250
- Publication type
Article