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- Title
Comparative Evaluation of Angiogenesis in Metastatic and Nonmetastatic Cases of Oral Squamous Cell Carcinoma: A Morphometric Analysis.
- Authors
Vanjani, Mukta V.; Phulari, Rashmi G. S.; Rathod, Rajendrasinh; Kantharia, Shehnaz; Saxena, Nidhi; Mistry, Yogesh
- Abstract
Introduction: Tumor angiogenesis has been correlated in metastasis of breast, lung, and prostate cancers; but the concept still remains unclear for oral squamous cell carcinoma (OSCC). A few studies state that angiogenesis shows a correlation with regional lymph node metastasis in OSCC and acts as an independent prognostic indicator, whereas others state that angiogenesis does not have any role. Aim: This study aims at evaluating whether angiogenesis plays a role in the regional lymph node metastasis in OSCC cases. Objectives are to quantify vasculature and evaluate mean vascular density (MVD), total vascular area (TVA), and mean vascular area (MVA) in OSCC, as morphometric parameters; to evaluate whether the depth of invasion (DOI) can act as an independent predictor of metastasis; to find its correlation with morphometric parameters; and to compare DOI with pathological TNM staging. Materials and methods: CD34 immunohistochemical staining was done for 90 OSCC resection cases (45 cases--pathologically node positive and 45 cases--node negative). Five representative hotspots for each slide were randomly selected. Photomicrographs were captured and subjected to the ImageJ software for morphometric analysis. Results: MVD, TVA, and MVA were found to be higher in the metastatic group as compared with the nonmetastatic group, with TVA showing highly significant results. DOI was found to be increased in the metastatic group, and a positive correlation was obtained between DOI and TVA, with a statistically significant p value. A statistical significant difference was obtained between DOI and pathological staging. Conclusion: TVA is considered to be the best and efficient predictor of metastasis. DOI has been found to be useful for predicting lymph node metastasis, defining its role as an independent predictor.
- Subjects
SQUAMOUS cell carcinoma; NEOVASCULARIZATION; METASTATIC breast cancer; MORPHOMETRICS; IMMUNOSTAINING; LYMPH nodes
- Publication
Oral & Maxillofacial Pathology Journal, 2019, Vol 10, Issue 2, p61
- ISSN
0976-1225
- Publication type
Article