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- Title
Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.
- Authors
Alam, S. Munir; Aussedat, Baptiste; Vohra, Yusuf; Meyerhoff, R. Ryan; Cale, Evan M.; Walkowicz, William E.; Radakovich, Nathan A.; Anasti, Kara; Armand, Lawrence; Parks, Robert; Sutherland, Laura; Scearce, Richard; Joyce, M. Gordon; Pancera, Marie; Druz, Aliaksandr; Georgiev, Ivelin S.; Von Holle, Tarra; Eaton, Amanda; Fox, Christopher; Reed, Steven G.
- Abstract
The article reports on the mimicry of an HIV infection in neutralizing antibody (bnAbs) epitope with a synthetic glycopeptide. It cites on the goal of the HIV vaccine in overcoming virus variability in inducing bnAbs. The article also reports on the study of ontogeny of the V3-glycan bnAb DH270 lineage in which an unmutated common ancestor (UCA) antibody for the DH270 lineage did not bind HIV-1 Env glycoprotein.
- Subjects
HIV infections; AIDS vaccines; IMMUNOGLOBULINS; GLYCANS; ONTOGENY; GLYCOPROTEINS
- Publication
Science Translational Medicine, 2017, Vol 9, Issue 381, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aai7521