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- Title
The chimeric transcript RUNX1-GLRX5: a biomarker for good postoperative prognosis in Stage IA non-small-cell lung cancer.
- Authors
Rie Ishikawa; Yosuke Amano; Masanori Kawakami; Mitsuhiro Sunohara; Kousuke Watanabe; Hidenori Kage; Nobuya Ohishi; Yutaka Yatomi; Jun Nakajima; Masashi Fukayama; Takahide Nagase; Daiya Takai
- Abstract
Stage IA non-small-cell lung cancer cases have been recognized as having a low risk of relapse; however, occasionally, relapse may occur. To predict clinical outcome in Stage IA non-small-cell lung cancer patients, we searched for chimeric transcripts that can be used as biomarkers and identified a novel chimeric transcript, RUNX1-GLRX5, comprising RUNX1, a transcription factor, and GLRX5. This chimerawas detected in approximately half of the investigated Stage IA non-small-cell lung cancer patients (44/104 cases, 42.3%). Although therewas no significant difference in the overall survival rate between RUNX1-GLRX5-positive and -negative cases (P = 0.088), a significantly lower relapse rate was observed in the RUNX1-GLRX5-positive cases (P = 0.039), indicating that this chimera can be used as a biomarker for good prognosis in Stage IA patients. Detection of the RUNX1-GLRX5 chimeric transcript may therefore be useful for the determination of a postoperative treatment plan for Stage IA non-small-cell lung cancer patients.
- Publication
Japanese Journal of Clinical Oncology, 2016, Vol 46, Issue 2, p185
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/jjco/hyv187