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- Title
Alterations in Gut Vitamin and Amino Acid Metabolism are Associated with Symptoms and Neurodevelopment in Children with Autism Spectrum Disorder.
- Authors
Zhu, Jiang; Hua, Xueying; Yang, Ting; Guo, Min; Li, Qiu; Xiao, Lu; Li, Ling; Chen, Jie; Li, Tingyu
- Abstract
Metabolic disturbance may be implicated in the pathogenesis of autism. This study aimed to investigate the gut metabolomic profiles of autistic children and to analyze potential interaction between gut metabolites with autistic symptoms and neurodevelopment levels. We involved 120 autistic and 60 neurotypical children. Autistic symptoms and neurodevelopment levels were assessed. Fecal samples were analyzed using untargeted liquid chromatography-tandem mass spectrometry methods. Our results showed the metabolic disturbances of autistic children involved in multiple vitamin and amino acid metabolism pathways, with the strongest enrichment identified for tryptophan metabolism, retinol metabolism, cysteine-methionine metabolism, and vitamin digestion and absorption. Differential gut metabolites were correlated to autistic symptoms and neurodevelopment levels. Our findings improved the understanding of the perturbations of metabolome networks in autism.
- Subjects
CHINA; AMINO acid metabolism; TRYPTOPHAN metabolism; VITAMIN A metabolism; CYSTEINE metabolism; METHIONINE metabolism; FECAL analysis; VITAMIN metabolism; GASTROINTESTINAL system; VITAMINS; METABOLOMICS; LIQUID chromatography; CROSS-sectional method; CHILDREN with disabilities; NEURAL development; RISK assessment; CELLULAR signal transduction; AUTISM; MASS spectrometry; DIGESTION; METABOLITES; DISEASE complications; SYMPTOMS; CHILDREN
- Publication
Journal of Autism & Developmental Disorders, 2022, Vol 52, Issue 7, p3116
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-021-05066-w