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- Title
Genetic Variants of the Protein Kinase C-β 1 Gene and Development of End-Stage Renal Disease in Patients With Type 2 Diabetes.
- Authors
Ma, Ronald C. W.; Tam, Claudia H. T.; Wang, Ying; Luk, Andrea O.; Hu, Cheng; Yang, Xilin; Lam, Vincent; Chan, Alfred W. H.; Ho, Janice S. K.; Chow, Chun-Chung; Tong, Peter C. Y.; Jia, Weiping; Ng, Maggie C. Y.; So, Wing-Yee; Chan, Juliana C. N.
- Abstract
The article discusses a study which investigated the risk association of protein kinase C-Β (PKC-Β) polymorphisms and end-stage renal disease (ESRD) in an 8-year prospective cohort with Chinese patients with type 2 diabetes. There has been an association between the cell-signaling intermediate PKC-Β and the development of diabetic complications. Eighteen common tag single-nucleotide polymorphisms (SNPs) were genotyped by the authors. It was concluded that genetic variants in the PRKCB1 gene were independently associated with development of ESRD.
- Subjects
CHINA; PROTEIN kinase C; CHRONIC kidney failure; TYPE 2 diabetes; DIABETES complications; GENETIC polymorphism research
- Publication
JAMA: Journal of the American Medical Association, 2010, Vol 304, Issue 8, p881
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2010.1191