We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genetic Loci Associated With C-Reactive Protein Levels and Risk of Coronary Heart Disease.
- Authors
Elliott, Paul; Chambers, John C.; Weihua Zhang; Clarke, Robert; Hopewell, Jemma C.; Peden, John F.; Erdmann, Jeanette; Braund, Peter; Engert, James C.; Bennett, Derrick; Coin, Lachlan; Ashby, Deborah; Tzoulaki, Ioanna; Brown, Ian J.; Mt-Isa, Shahrul; McCarthy, Mark I.; Peltonen, Leena; Freimer, Nelson B.; Farrall, Martin; Ruokonen, Aimo
- Abstract
The article discusses a study aimed at conducting a genome-wide association analysis to identify common genetic variants associated with C-reactive protein (CRP) levels and coronary heart disease. A mendelian randomization study of the most closely associated single-nucleotide polymorphism (SNP) in the CRP locus was conducted by the researchers. Findings were compared with that predicted from meta-analysis of observational studies of CRP levels. It was concluded that there was no causal association between CRP levels and coronary heart disease.
- Subjects
C-reactive protein; CORONARY disease; MEDICAL genetics; HEART disease genetics; HUMAN genome; META-analysis; GENETICS
- Publication
JAMA: Journal of the American Medical Association, 2009, Vol 302, Issue 1, p37
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2009.954