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- Title
SDF-1/CXCR4 Axis Promotes MSCs to Repair Liver Injury Partially through Trans-Differentiation and Fusion with Hepatocytes.
- Authors
Hao, Ning-Bo; Li, Chang-Zhu; Lü, Mu-Han; Tang, Bo; Wang, Su-Min; Wu, Yu-Yun; Liang, Guang-Ping; Yang, Shi-Ming
- Abstract
MSCs have become a popular target for developing end-stage liver therapies. In this study, two models of bone marrow chimeric mice were used to construct the liver failure models. Then it was found that MSCs can transdifferentiate into hepatocyte-like cells and these hepatocyte-like cells can significantly express albumin. Furthermore it was also found that MSCs can fuse with the hepatocytes and these cells had the proliferation activity. However, the percentage of transdifferentiation was significantly higher than fusion. So it was considered that MSCs which transdifferentiated into hepatocyte-likes cells played important roles for repairing the injuring liver function.
- Subjects
MESENCHYMAL stem cell differentiation; LIVER injuries; THERAPEUTICS; LIVER cells; BONE marrow physiology; LABORATORY mice; CELL proliferation
- Publication
Stem Cells International, 2015, Vol 2015, p1
- ISSN
1687-966X
- Publication type
Article
- DOI
10.1155/2015/960387