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- Title
Etanercept Combined with Glucocorticoid and Gamma Globulin for Treating Children with Toxic Epidermal Necrolysis: A Case Report.
- Authors
Fu, Yanhua; Xiao, Yuanyuan; Gao, Tianji; Zhang, Junxiu; Wang, Tianjiao
- Abstract
Toxic epidermal necrolysis (TEN) is a type of drug eruption in dermatology emergencies that is rare in clinical practice but has a high mortality rate. The main causes are drug and viral infections. Unfortunately, no expert consensus on treating this disease exists, and a standard therapy is absent. Up to now, glucocorticoids combined with gamma globulin are commonly used in clinical practice, but their efficacy is highly controversial. This study reports on a 7-year-old girl with TEN who did not respond to traditional therapy, such as methylprednisolone combined with gamma globulin, but was finally cured with an additional low-dose etanercept. The results showed that etanercept therapy in paediatric TEN is safe, reliable and worth recommending.
- Subjects
TOXIC epidermal necrolysis; ETANERCEPT; GLOBULINS; DRUG eruptions; GLUCOCORTICOIDS; VIRUS diseases
- Publication
Clinical, Cosmetic & Investigational Dermatology, 2024, Vol 17, p167
- ISSN
1178-7015
- Publication type
Case Study
- DOI
10.2147/CCID.S440476