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- Title
Endothelin Receptor Antagonists for the Treatment of Raynaud's Phenomenon and Digital Ulcers in Systemic Sclerosis.
- Authors
Arefiev, Kait; Fiorentino, David F.; Chung, Lorinda
- Abstract
Systemic sclerosis is a connective tissue disease characterized by fibrosis of the skin, internal organs, and widespread vasculopathy. Raynaud's phenomenon and digital ulcers are vascular manifestations of this disease and cause significant morbidity. Current treatments are only moderately effective in reducing the severity of Raynaud's in a portion of patients and typically do not lead to substantial benefit in terms of the healing or prevention of digital ulcers. Several studies have evaluated the efficacy of targeting the vasoconstrictor endothelin-1 for the treatment of systemic sclerosis-associated vascular disease. The purpose of this paper is to summarize the published studies and case reports evaluating the efficacy of endothelin receptor antagonists in the treatment of Raynaud's phenomenon and digital ulcers associated with systemic sclerosis.
- Subjects
ENDOTHELIN receptors; RAYNAUD'S disease; ULCERS; SYSTEMIC scleroderma; MUSCULOSKELETAL system; ENDOTHELINS; VASCULAR diseases; SUPPURATION
- Publication
International Journal of Rheumatology, 2011, Vol 2011, p1
- ISSN
1687-9260
- Publication type
Article
- DOI
10.1155/2011/201787