We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Microcystic adnexal carcinoma: a light microscopic, immunohistochemical and ultrastructural study.
- Authors
Kato, Haruhisa; Mizuno, Nobuyuki; Nakagawa, Koichi; Furukawa, Masayoski; Hamada, Toshio
- Abstract
We report a case of microcystic adnexal carcinoma (MAC) occurring on the upper lip of an 82-year-old woman. Microscopically the tumor showed both pilar and sweat gland differentiation, involved the entire dermis and subcutaneous tissue, and invaded perineural spaces. Immunoperoxidase studies revealed carcinoembrionic antigen to be present in the ductal lining cells and in the amorphous content in the lumen, confirming sweat gland differentiation. The S-100 protein was positive in dendritic cells within the solid cell nests, but negative in cells lining cystic spaces. Ultrastructural study confirmed that the neoplasm was composed of two components, with pilar and eccrine differentiation. The former showed concentric layers of squamous epithelial cells with well-developed desmosomes and cytofilaments. The latter had ductal and alveolar structures; the ultrastructural features included i) numerous villous folds of plasma membrane to interdigitate each other by focal desmosomes, ii) aggregates of cytofilaments, and iii) basally located myoepithelial cells which were separated from the surrounding stroma by rather thick basement membrane. In addition, distinct amyloid deposition was also observed on ultrastructural examination. To our knowledge, amyloid deposition has not been previously reported in MAC.
- Subjects
CANCER; TUMORS; SWEAT glands; IMMUNOENZYME technique; ANTIGENS; DESMOSOMES
- Publication
Journal of Cutaneous Pathology, 1990, Vol 17, Issue 2, p87
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/j.1600-0560.1990.tb00062.x