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- Title
Effective Induction Therapy with Subcutaneous Administration of Bortezomib for Newly Diagnosed POEMS Syndrome: A Case Report and a Review of the Literature.
- Authors
Zeng, Ke; Yang, Jin-rong; Li, Jun; Wei, Qing; Yang, Yi-ming; Liu, Ting; Niu, Ting
- Abstract
POEMS syndrome is characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes. Bortezomib is an important component of the chemotherapy regimen associated with multiple myeloma, and has been previously applied to POEMS syndrome. We present a 56-year-old Chinese man who was given subcutaneous administration of bortezomib as part of the BDex (bortezomib-dexamethasone) regimen for his POEMS syndrome. The peripheral neuropathy and laboratory- test results of the patient improved dramatically with 4 cycles of treatment, resulting in a complete response. In addition, the treatment was well tolerated and adequate peripheral blood hematopoietic stem cells were collected for an ensuing autologous stem cell transplant.
- Subjects
SUBCUTANEOUS infusions; BORONIC acids; POEMS syndrome; CASE studies; MEDICAL literature reviews; DRUG administration; AUTOTRANSPLANTATION; STEM cell transplantation; DIAGNOSIS
- Publication
Acta Haematologica, 2013, Vol 129, Issue 2, p101
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000343681